Buy Cialis Online Without Prescription

Cialis is the brand name of the drug Tadalafil and is an effective drug used in the treatment of erectile dysfunction. The same drug under the name of Adcirca is used for the treating Pulmonary arterial hypertension. This drug was originally developed by ICOS and marketed all over the world by Lilly ICOS which is the joint venture of Eli Lilly and ICOS Corporation. It is also manufactured and sold by Cipla (an Indian pharmaceutical company) under the brand name if Tadacip.

It is noteworthy that drug Cialis was released after the launch of Viagra which hit the market with the wide publicity for the treatment of erectile dysfunction. In fact Cialis was the third drug to get the FDA approval for the treatment fro erectile dysfunction after Viagra and Levitra. But there are differences between these drugs and Cialis in their mechanism of action and the effectiveness. For example Cialis is the only drug among these three that is to be taken once daily. Moreover, Tadalafil is also approved by FDA for treatment of the pulmonary hypertension.

Mechanism of Action of Cialis

Although the drugs Viagra, Levitra and Cialis result in penile erection by the same mechanism, Cialis has a longer half life time compared to other two drugs. It has half life of 17.5 hours while Viagra and Levitra have comparatively very short half life of just 4 to 5 hours. The active component of Cialis acts as a PDE5 inhibitor. In order to get the penile erection the increased blood flow under the sexual stimulation is caused by relaxed penile arteries and smooth muscles in the corpus cavernosum, This is triggered b the release of nitric oxide at the nerve endings and endothelial cells. This causes the synthesis of cGMP in the cells of the smooth muscles. This directly causes the relaxation of the smooth muscles thereby increasing the blood flow to corpus cavernosm. If PDE5 is inhibited the amount of cGMP enhances the erectile function. But the intervention of Cialis to inhibit PDE5 at this stage would have no effect if there were no sexual stimulation. Unless the individual is not sexually stimulated the drug will not cause spontaneous erection by taking Cialis.

Side effects of Cialis

Is it safe to use Cialis? Moreover, this question is important because you are able to buy Cialis online without prescription. Clinical trials conducted on 15000 men by the use of millions of men all over the world it is observed that the side effects of Cialis are not of grave nature. Common side effects observed are headache, back pain, indigestion, muscle ache, running nose and flushing. These effects are due to the mechanism of Cialis as PDE5 inhibitor which will cause the blood vessels to dilate. These minor effects usually vanish after few hours. IN case of back pain and muscle aches, they appear after 12 hours to 2 hours and may require 2 to 3 days to disappear.

In 2005 FDA reported that taking Cialis was having some association in causing vision impairment which was related to a condition known as NAION. These were the reports about the drug usage outside the clinical trials. But at the same time, it was found that the patients who developed vision impairment due to NAION had other factors like crowded disc, diabetes, age above 50, hypertension and smoking that are known to contribute to NAION. Still it was necessary to include the warning about the possibility of vision impairment. But the occurrence observed in a very small population of 1 in one million and other possible causes do not pose a serious risk on this possibility. In 2007, FDA made it mandatory to include the warning of risk of sudden hearing loss as the reports of post marketing surveys indicated about all PDE5 inhibiting drug side effects.

How to buy Cialis online without prescription? Various surveys like clinical trials and post marketing reports have established the safety of Cialis. The drug has been in use by millions of people all over the world. This vouches for the safety of the drug and that, it is safe to buy Cialis online without prescription.

Online stores offer to supply you the drugs for erectile dysfunction and these drugs are from safe sources. If you buy Cialis online without prescription you have several advantages like a high discount on the purchases and usually they offer free shipping. For the people who hesitate to visit drug stores for buying the impotence pills, it is very easy to buy Cialis online without prescription.

But certain precautions are needed to be exercised before buying Cialis online. The most important of them is that Generic Cialis is not FDA approved drug and it should not be taken at all. If any website claims that it is selling generic Cialis you must realize that this is being done illegally. Cialis is a patented drug and hence it can not be sold as generic drug. But such sites may be operating from outside US where it may not be illegal. But that is an irrelevant issue as you must give utmost care in buying genuine Cialis from reliable sources.